Here, we show that chronic pancreatitis and ADM in genetically wild type mice results in the formation of a significant population of chemosensory tuft cells. ADM is a cell type transdifferentiation event where pancreatic acinar cells become ductal-like under conditions of injury or oncogenic mutation.

4Flow Cytometry Core, Salk Institute for Biological Studies, La Jolla, CA, United StatesĬhronic pancreatitis, a known risk factor for the development of pancreatic ductal adenocarcinoma (PDA), is a serious, widespread medical condition characterized by inflammation, fibrosis, and acinar to ductal metaplasia (ADM).

3Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States.

2Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, CA, United States.

1Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, United States.Naeem 1†, Linjing Fang 2, Chi-Yeh Chung 1‡, Cynthia Ramos 1, Natalie Luhtala 3, Carolyn O’Connor 4, Tony Hunter 3, Uri Manor 2 and Geoffrey M.

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